The association of point-of-care coagulation testing with bleeding symptoms in patients with Ehlers–Danlos syndrome: an exploratory cross-sectional study
Authors' conclusion
Point-of-care functional platelet testing using aggregation in response to an exogenous collagen agonist may detect inherent platelet dysfunction in patients with hypermobile subtype. We did not detect any ROTEM parameter abnormalities that were associated with elevated BSS scores.
Study context
- Population
- Adults with Ehlers-Danlos Syndromes (EDS), GoodHope EDS Clinic, Toronto General Hospital, 27 April 2022 to 7 October 2024
- Participants
- 17 adults
- Exposure
- Hypermobile vs classical EDS subtype; Point-of-care (POC) testing vs bleeding history
- Hypermobilen = 10
- Classicaln = 7
- Outcome
- Association between BSS (ISTH-BAT) and POC parameters (ROTEM, functional platelet testing)
Methodological detailsexploratory, single-centre
- Exploratory
- Single-centre
Main finding
As reported in the abstract
Association of POC parameters with BSS
- No significant abnormalities detected using rotational thromboelastometry (ROTEM)
- Lower functional platelet percentages in hypermobile subgroup, with no association with Bleeding Severity Score (BSS)
Observational data: associations, not effects.
Further findings
Clinically significant bleeding (BSS ≥ 4 in males; ≥ 6 in females)
Major surgery or trauma
- Patients with major surgery or trauma
- 9 (53%)
- Median age at major surgery or trauma (range 8-39), yr
- 23
Original publication
The association of point-of-care coagulation testing with bleeding symptoms in patients with Ehlers–Danlos syndrome: an exploratory cross-sectional study. Can J Anaesth. Published 19 December 2025. doi:10.
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