The Beneficial and Harmful Effects of Perioperative Clonidine: Protocol for a Systematic Review With Meta‐Analysis
Study context
- Population
- Patients undergoing surgery (postoperative pain management)
- Planned comparison
- Perioperative systemic clonidine vs placebo or no intervention
- Primary endpoint
- Postoperative pain intensity and serious adverse events
Methodological detailsPRISMA-P, Grading of Recommendations Assessment, Development, and Evaluation (GRADE), Search of Medline, Embase and Cochrane Central Register of controlled trials
- PRISMA-P
- GRADE
- Search of Medline, Embase and Cochrane Central Register of controlled trials
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
The Beneficial and Harmful Effects of Perioperative Clonidine: Protocol for a Systematic Review With Meta‐Analysis. Acta Anaesthesiol Scand. Published 15 July 2025. doi:10.
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