ICU sedation, delirium & recovery

The Benefits of Early Rehabilitation for Patients With Acute Heart Failure Requiring IV Inotropic Drugs

Crit Care MedPublished Retrospective cohort study

Main finding · In-hospital mortalityResult — go to the resultRelative risk 0.75 95% CI 0.67–0.83

Authors' conclusion

The early prescription of rehabilitation was associated with favorable short-term outcomes even for patients with acute HF requiring IV inotropic drugs.

Study context

Population
Patients with acute heart failure (HF) requiring IV inotropic drugs within 2 days of admission, data covering more than 90% of patients at a tertiary emergency hospital in Japan
Participants
38,302 patients · 5,126 matched pairs
Exposure
Early rehabilitation vs no early rehabilitation
  • Early rehabilitationn = 5,126
  • Controln = 5,126reference
Outcome
In-hospital mortality
Methodological detailspropensity-score matched
  • Propensity-score matched

Main finding

As reported in the abstract

Relative risk

0.75

95% CI 0.67–0.83

P < 0.001

By group

Early rehabilitation vs Control
RR 0.75 (95% CI 0.67–0.83); P < 0.001

Observational data: associations, not effects.

Further findings

30-day all-cause readmission

P = 0.001

30-day HF readmission

P = 0.002

OutcomeEarly rehabilitationControlP value
Length of stayMean25.527.1P < 0.001
Barthel Index (BI) at discharge6867P = 0.096

Subgroups (age ≥80 years, BMI <18.5 kg/m 2, Barthel Index (BI) <60)

Consistent findings across subgroups

Original publication

The Benefits of Early Rehabilitation for Patients With Acute Heart Failure Requiring IV Inotropic Drugs. Crit Care Med. Published 30 October 2024. doi:10.1097/ccm.0000000000006462

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