The challenging diagnosis of ICU-related Mesenteric Ischaemia: a prospective, observational, multicentre cohort

doi:10.1016/j.aicoj.2026.100028

Organ support & nutrition

The challenging diagnosis of intensive care unit (ICU)-related Mesenteric Ischaemia: a prospective, observational, multicentre cohort

Ann Intensive CarePublished 21 Jan 2026Prospective observational cohort study

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Authors' conclusion

This is the first study to propose a combined approach for predicting NB in ICU patients with suspected AMI.

Study context

Population: ICU patients with suspected acute mesenteric ischaemia (acute mesenteric ischemia (AMI))
Participants: 202 patients

Exposure: Patients with necrotic bowel (NB) at surgical exploration vs without NB
NBn = 74
No NBn = 128reference
Outcome: Parameters independently associated with necrotic bowel (NB)

Methodological detailsmulticentre, three ICUs, consecutive patients

Multicentre
Three ICUs
Consecutive patients

Main finding

As reported in the abstract

Independent predictors of NB (multivariable logistic regression)

NB37%74

No NB63%128

Odds ratio (95% CI)P value

Age

1.068(1.027–1.111)

P = 0.001

Active fluid removal

3.148(1.19–8.33)

P = 0.021

Need for RRT

3.834(1.457–10.01)

P = 0.006

Lactate dehydrogenase (log) at AMI suspicion

7.135(2.1–24.235)

P = 0.002

Signs of gastrointestinal injury: 3.432 (95% CI 1.082–10.885); P = 0.036

Observational data: associations, not effects.

Further findings

Biomarker discrimination (AUC)

Lactate dehydrogenase showed the highest AUC among biomarkers

Original publication

The challenging diagnosis of ICU-related Mesenteric Ischaemia: a prospective, observational, multicentre cohort. Ann Intensive Care. Published 21 January 2026. doi:10.1016/j.aicoj.2026.100028

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