Anticoagulation management and outcomes in critically ill patients with acute mesenteric ischemia: an international study
Main finding · 30-day survivalResult — go to the resultNNT 8Authors' conclusion
This study suggests a significant survival benefit of early full-dose anticoagulation in ICU patients with acute mesenteric ischemia and no difference in hemorrhagic complications. Early full-dose anticoagulation and revascularization and/or bowel resection were associated with survival.
Study context
- Population
- Critically ill intensive care unit (ICU) patients with acute mesenteric ischemia, 33 ICU centres in 19 countriesanalysed
- Participants
- 370 patients
- Exposure
- Early full-dose anticoagulation vs no early full-dose anticoagulation
- Early full-dose anticoagulationn = 183
- No early full-dose anticoagulationn = 187reference
- Outcome
- 30-day survival
- Follow-up
- 30 days
Main finding
As reported in the abstract
NNT
8
P = 0.01
Events by group
Observational data: associations, not effects.
Secondary outcomes
| Outcome | P value |
|---|---|
| Duration of mechanical ventilationLonger with early full-dose anticoagulation | P = 0.01 |
| 90-day survival | P = 0.02 |
- 90-day survival: improved survival persisted with early full-dose anticoagulation
ICU LOS
- No differences observed
Independent factors for 30-day survival (multivariate Cox models)
- Only early full-dose anticoagulation and revascularization and/or bowel resection associated with survival
- Four multivariate Cox hazard models
Safety
Hemorrhagic complications
- No differences observed
Original publication
Anticoagulation management and outcomes in critically ill patients with acute mesenteric ischemia: an international study. Intensive Care Med. Published 16 June 2025. doi:10.
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