The comparison of caesarean section bleeding between volatile and total intravenous anaesthesia in a Japanese nationwide database
Authors' conclusion
This large observational study with instrumental variable analyses suggested an increased bleeding risk associated with volatile anaesthesia, and the results were not identical to those in the conventional regression analyses.
Study context
- Population
- Women undergoing caesarean section under GA, Japanese nationwide inpatient database, April 2012 to March 2020
- Participants
- 26,585 women
- Exposure
- Volatile anaesthesia vs total intravenous anaesthesia (TIVA) for caesarean section under GA
- Volatilen = 19,320
- TIVAn = 7,265reference
- Outcome
- Volume of blood loss
Methodological detailsnationwide inpatient database, instrumental variable analysis
- Nationwide inpatient database
- Instrumental variable analysis
Main finding
As reported in the abstract
Blood loss
Volatile vs TIVAAdjusted mean difference (95% CI)
Conventional regression analyses
−56.1(−81.4 to −30.7)
Volatile vs TIVAAdjusted mean difference, ml (95% CI)
Instrumental variable analysis
154.3(112.4–196.3)
Observational data: associations, not effects.
Further findings
Blood transfusion
Original publication
The comparison of caesarean section bleeding between volatile and total intravenous anaesthesia in a Japanese nationwide database. Eur J Anaesthesiol Intensive Care. Published 29 March 2023. doi:10.
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