The economic value of preventing projected sepsis-related deaths among adults in 79 countries, 2000–2023, with projections to 2050: a modelling study
Authors' conclusion
Although sepsis-related mortality has increased, most deaths remain avoidable, suggesting substantial scope for improvement.
Study context
- Population
- Adults aged ≥ 20 years in 79 countries of the World Health Organization (WHO) Mortality Database, 2000–202379 countries
- Outcome
- Sepsis-related mortality trends and economic value of reducing avoidable deaths (mortality above 20th percentile frontier), as proportion of annual income in 2021 Int$
- Follow-up
- 2000-2023, projections to 2050
Methodological detailsBayesian neural network age-period-cohort projections, frontier model, value of a statistical life, Analyses stratified by age, sex and five World Bank-based regions
- Bayesian neural network age-period-cohort projections
- Frontier model
- Value of a statistical life
- Analyses stratified by age, sex and five World Bank-based regions
Main finding
As reported in the abstract
Global age-standardised sepsis mortality and economic value of avoidable deaths · 2023
- Age-standardised mortality rate, 2000 (deaths per 100,000)
- 9.15
- Age-standardised mortality rate, 2023
- 12.77 (deaths per 100,000; 95% CI 8.67-17.72)
- Projected age-standardised mortality rate, 2050
- 20.32 (95% CI 14.61-27.55)
- Proportion of sepsis-related mortality avoidable, 2023
- 61.34%
- Global economic value of reducing avoidable deaths, 2023
- Int$ 62.6 billion
- Economic value as proportion of annual income, 2023
- 1.41%
Observational data: associations, not effects.
Further findings
Economic value as proportion of annual income, by sex · 2023
- Males
- 1.48%
- Females
- 1.35%
Economic value as proportion of annual income, by region · 2023
- North America (highest)
- 1.80%
- Europe and Central Asia (lowest)
- 1.00%
Original publication
The economic value of preventing projected sepsis-related deaths among adults in 79 countries, 2000–2023, with projections to 2050: a modelling study. Crit Care. Published 20 April 2026. doi:10.
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