Hemodynamics, fluids & transfusion
The Effect of Albumin Administration in Critically Ill Patients: A Retrospective Single-Center Analysis
Authors' conclusion
Hemodilution was observable for at least 12 hours after albumin administration and may have caused a decrease in hemoglobin concentration of greater than 8 g/L when isooncotic albumin solution (5%, 25 g in 500 mL) was administered.
Study context
- Population
- Adult ICU admissions staying at least 24 hours, University Hospital Basel, Switzerland, January 2013 to December 2021
- Participants
- 20,927 admissions
- Exposure
- Albumin administration vs matched controls
- Albuminn = 3,748
- Outcome
- Proportion of critically ill patients treated with albumin
- Follow-up
- 2013 to 2021
Methodological detailssingle-centre, matched control group
- Single-centre
- Matched control group
Main finding
As reported in the abstract
Proportion treated with albumin rose from 2013 to 2021
5.0% to 32.5%
Increase in surgical patients
4.7-47.2%
Increase in those receiving RBC transfusion
13.7-72.6%
Observational data: associations, not effects.
Further findings
Hemoglobin change after albumin (volume expansion)
- Significant drop in hemoglobin after albumin, on average around
- 5 g/L
- 2006 admissions met volume-expansion inclusion criteria
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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