Perioperative medicine & outcomes
The effect of diabetes mellitus on perioperative outcomes after colorectal resection: a national cohort study
Authors' conclusion
People with diabetes mellitus undergoing colorectal resection are at a higher risk of 90-day mortality, prolonged LOS, and 90-day readmission, with use of insulin associated with additional risk.
Study context
- Population
- Adults with colorectal resection in England, 2010–2020 (Hospital Episode Statistics linked to Clinical Practice Research Database)49.8% male
- Participants
- 106,139 adults
- Exposure
- Diabetes mellitus vs no diabetes
- Diabetes mellitusn = 10,931
- Insulinn = 2,145
- Outcome
- Mortality
- Follow-up
- 90 days
Methodological detailsnational cohort, linked registry data
- National cohort
- Linked registry data
Main finding
As reported in the abstract
90-day mortality
Each group vs no diabetesAdjusted hazard ratio (95% CI)P value
Diabetes mellitus
1.28(1.19–1.37)
P < 0.001Insulin
1.51(1.31–1.74)
P < 0.001No insulin
1.22(1.13–1.33)
P < 0.001- Unadjusted 90-day mortality risk, whole cohort
- 5.7%
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| Readmission within 90 daysDiabetes mellitus vs No diabetes | 1.23 (1.18–1.29) | P < 0.001 | |
| 0.512Adjusted hazard ratio (log scale) |
| Outcome | Adjusted time ratio (95% CI) | P value |
|---|---|---|
| Hospital LOSDiabetes mellitus vs No diabetes | 1.10 (1.08–1.11) | P < 0.001 |
- Readmission within 90 days — Readmission, whole cohort
- 20 542 (19.4%)
- Hospital length of stay (LOS) — Median (IQR) LOS, whole cohort, days
- 8 (5-15)
Original publication
The effect of diabetes mellitus on perioperative outcomes after colorectal resection: a national cohort study. Br J Anaesth. Published 16 May 2024. doi:10.
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