The effect of duration of antimicrobial treatment for bacteremia in critically ill patients on in-hospital mortality – Retrospective double center analysis
Authors' conclusion
In this restrospective study, we found no evidence for a survival benefit of longer (>10 days) versus shorter treatment course in ICU patients with bacteremia.
Study context
- Population
- Critically ill patients with bacteremia at two Swiss tertiary Intensive Care Units (ICUs), excluding infections requiring prolonged treatment and single contaminant culturesincluded in primary analysis
- Participants
- 382 patients
- Exposure
- Shorter vs longer adequate antimicrobial treatment
- Outcome
- Time from start of antimicrobial treatment to in-hospital death or hospital discharge, whichever first
Methodological detailsdouble centre, time-dependent Cox model, cloning approach
- Double centre
- Time-dependent Cox model
- Cloning approach
Main finding
As reported in the abstract
Time from start of antimicrobial treatment to in-hospital death or discharge (in-hospital survival)
- No differences in in-hospital survival between shorter and longer treatment
- Methods to mitigate confounding and immortality bias
Observational data: associations, not effects.
Secondary outcomes
Duration of antibiotic therapy, overall
- Median duration of antibiotic therapy (IQR, 7-20)
- 14 days
Sensitivity analysis, 7-day cut-off
- Interpretation did not change when using a 7 days cut-off
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The effect of duration of antimicrobial treatment for bacteremia in critically ill patients on in-hospital mortality – Retrospective double center analysis. J Crit Care. Published 23 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →