Cardiac arrest & resuscitation
The effect of higher or lower mean arterial pressure on kidney function after cardiac arrest: a post hoc analysis of the COMACARE and NEUROPROTECT trials
Authors' conclusion
We found no difference in the incidence of AKI between the patients treated with lower and those treated with higher MAP after CA.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) patients
- Participants
- 227 patients
- Comparison
- High-normal mean arterial pressure (MAP) vs Low-normal MAP
- High-normal MAPn = 115
- Low-normal MAPn = 112reference
- Primary endpoint
- Incidence of AKI (Kidney Disease Improving Global Outcome (KDIGO) classification)
- Follow-up
- First five days
Methodological detailspost hoc analysis
- Post hoc analysis
Primary result
As reported in the abstract
AKI
High-normal MAP
40
events
Low-normal MAP
46
events
P = 0.51
- Acute kidney injury (AKI) overall
- 86 (38%)
Further findings
Creatinine
Daily urine output
Independent AKI predictors (Cox regression)
- No bystander CPR
- P < 0.01
- Non-shockable rhythm
- P < 0.01
- Chronic hypertension
- P = 0.03
- Time to ROSC
- P < 0.01
- MAP target not an independent predictor
- P = 0.29
Original publication
The effect of higher or lower mean arterial pressure on kidney function after cardiac arrest: a post hoc analysis of the COMACARE and NEUROPROTECT trials. Ann Intensive Care. Published 21 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →