The effect of intravenous dexamethasone on rebound pain after wrist and hand surgery under supraclavicular brachial plexus blockade: a randomized placebo-controlled trial
Primary result · Pain score difference (before vs after block resolution)Result — go to the resultMean difference 2.6 95% CI 1.5–3.7Authors' conclusion
Preoperative administration of 0.11 mg·kg-1 intravenous dexamethasone significantly reduced rebound pain within 24 hr after wrist and hand surgery under supraclavicular brachial plexus blockade.
Study context
- Population
- Patients scheduled for elective wrist and hand surgery under supraclavicular brachial plexus blockade
- Participants
- 56 patients
- Comparison
- Control vs Dexamethasone
- Primary endpoint
- Difference in pain scores before vs after block resolution
Methodological detailsplacebo-controlled
- Placebo-controlled
Primary result
As reported in the abstract
Pain score difference (before vs after block resolution)
Mean difference
2.6
95% CI 1.5–3.7
P < 0.001
By group
Control
7.3
mean · SD 1.9
Dexamethasone
4.7
mean · SD 2.1
Control vs Dexamethasone
mean difference 2.6 (95% CI 1.5–3.7); P < 0.001
Secondary outcomes
Incidence of rebound pain
P < 0.001
Cumulative opioid consumption · 24 hr
P < 0.001
Safety
- No significant differences in postoperative complications
Original publication
The effect of intravenous dexamethasone on rebound pain after wrist and hand surgery under supraclavicular brachial plexus blockade: a randomized placebo-controlled trial. Can J Anaesth. Published 20 June 2025. doi:10.
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