Hemodynamics, fluids & transfusion
The effect of intravenous milrinone in adult critically ill patients: A meta-analysis of randomized clinical trials
Authors' conclusion
The meta-analysis showed when compared with control group, although no significant reduction in mortality and the incidence of myocardial infarction was found in the milrinone group, the incidence of ventricular arrhythmia decreased significantly in patients with cardiac surgery.
Study context
- Population
- Adult critically ill patients
- Participants
- 2,036 patients · 20 studies
- Comparison
- Milrinone vs control
- Outcome
- All-cause mortality
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
As reported in the abstract
- No significant difference in all-cause mortality vs control
Further pooled results
Ventricular arrhythmia (subgroups)
- Incidence decreased significantly with milrinone in cardiac surgery patients, but not in patients with cardiac dysfunction and shock
MI
- No significant reduction with milrinone
Hemodynamic parameters
- No improvement with milrinone
Trial sequential analysis
- Lack of firm evidence for a beneficial effect
Original publication
The effect of intravenous milrinone in adult critically ill patients: A meta-analysis of randomized clinical trials. J Crit Care. Published 28 October 2023. doi:10.
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