Perioperative medicine & outcomes
The effect of opioid-free anaesthesia on the quality of recovery after endoscopic sinus surgery: A multicentre randomised controlled trial
Authors' conclusion
OFA can provide good intraoperative analgesia and postoperative recovery quality as effectively as conventional opioid anaesthesia in patients undergoing ESS.
Study context
- Population
- Patients scheduled for elective endoscopic sinus surgery (ESS), 7 hospitals, May–December 2021773 analysed
- Participants
- 800 patients
- Comparison
- Opioid-free anaesthesia (OFA) vs opioid anaesthesia in ESS
- OFAn = 388
- Opioid anaesthesian = 385reference
- Primary endpoint
- Postoperative quality of recovery (QoR) (Quality of Recovery-40 questionnaire)
- Follow-up
- 24 h
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Quality of Recovery-40 total score
OFA
191
median · IQR 185–196
Opioid anaesthesia
194
median · IQR 187–197
P = 0.0014
Secondary outcomes
| Outcome | OFA | Opioid anaesthesia | P value |
|---|---|---|---|
| Postoperative pain NRS score · 30 min, 1 h, 2 h, 24 h30 min | P = 0.0017 | ||
| Postoperative pain NRS score · 30 min, 1 h, 2 h, 24 h1 h | P = 0.0052 | ||
| Postoperative pain NRS score · 30 min, 1 h, 2 h, 24 h2 h | P = 0.0079 | ||
| Postoperative pain NRS score · 30 min, 1 h, 2 h, 24 h24 h | P = 0.0303 | ||
| AUC of pain scale scoresSignificant | 24.2 (range or IQR as printed 3.0–47.5) | 11.5 (range or IQR as printed 1.0–39.0) | P = 0.0042 |
Postoperative pain NRS score · 30 min, 1 h, 2 h, 24 h
- Significant differences between groups at each time point
Safety
PONV · significantly lower with OFA
P = 0.0021
Original publication
The effect of opioid-free anaesthesia on the quality of recovery after endoscopic sinus surgery: A multicentre randomised controlled trial. Eur J Anaesthesiol. Published 29 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →