Perioperative medicine & outcomes
The effect of postoperative hypotension on surgical patients' adverse clinical outcomes: A systematic review and meta-analysis
Pooled result · MortalityResult — go to the resultOdds ratio 2.51 95 % CI 1.86–3.38Authors' conclusion
These findings establish POH as a clinically significant correlate of postoperative mortality and myocardial injury. However, POH associations with AKI and stroke exhibit limited robustness, requiring further investigation.
Study context
- Population
- Surgical patients
- Participants
- 262,435 patients · 23 studies
- Comparison
- Postoperative hypotension vs no postoperative hypotension (POH)
- Outcome
- Mortality during follow-up
Methodological detailsleave-one-out sensitivity analysis, subgroup analysis, Egger's test and trim-and-fill analysis, Searched PubMed, Web of Science, Cochrane Library, and Embase through 7 February 2025
- Leave-one-out sensitivity analysis
- Subgroup analysis
- Egger's test and trim-and-fill analysis
- Searched PubMed, Web of Science, Cochrane Library, and Embase through 7 February 2025
Pooled result
Mortality
Odds ratio
2.51
95 % CI 1.86–3.38
POH vs No POH
OR 2.51 (95 % CI 1.86–3.38)
As reported in the abstract
Further pooled results
| Outcome | OR (95 % CI) | |
|---|---|---|
| AKI | 1.72 (1.25–2.36) | |
| Myocardial injury | 2.52 (1.71–3.69) | |
| StrokeUnstable in leave-one-out sensitivity analyses | 1.82 (1.09–3.05) | |
| 0.20.5125Odds ratio (log scale) |
- Acute kidney injury (AKI): publication bias detected by trim-and-fill compromised robustness
Heterogeneity (subgroup analyses)
- Multiple POH thresholds the primary source of heterogeneity
Original publication
The effect of postoperative hypotension on surgical patients' adverse clinical outcomes: A systematic review and meta-analysis. J Clin Anesth. Published 30 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →