The effect of sugammadex on patient morbidity and quality of recovery after general anaesthesia: a systematic review and meta-analysis
Pooled result · PPCsResult — go to the resultOdds ratio 0.67 95% CI 0.47–0.95Authors' conclusion
Although few trials reported on DAOH-30 or important patient outcomes, sugammadex is associated with a reduction in postoperative pulmonary complications, however, this might not translate to a difference in hospital length of stay, patient-reported quality of recovery, or mortality.
Study context
- Population
- Patients receiving NMBA reversal after GA, in randomised trials reporting important patient outcomes beyond the PACU43 articles
- Participants
- 5,839 patients
- Comparison
- Sugammadex vs anticholinesterase-based or placebo reversal
- Outcome
- PPCs
Pooled result
As reported in the abstract
Odds ratio
0.67
95% CI 0.47–0.95
Sugammadex vs Control
OR 0.67 (95% CI 0.47–0.95)
Further pooled results
| Outcome | Sugammadex | Estimate | |
|---|---|---|---|
| DAOH-30 (sugammadex vs neostigmine-based reversal) · 30 daysOne trial | 25 (range 19–27) days | median difference 0.00 (CI −2.15 to 2.15) | |
| Hospital LOS23 trials | mean difference −0.31 (CI −0.84 to 0.22) | ||
| −3−2−10123Difference (linear scale) |
| Outcome | OR (CI) | |
|---|---|---|
| PneumoniaEight trials | 0.51 (0.24–1.01) | |
| Mortality11 trials · rarity of events precludes definitive conclusions | 0.39 (0.15–1.01) | |
| 0.10.31310Odds ratio (log scale) |
- DAOH-30 (sugammadex vs neostigmine-based reversal): Neostigmine 24 (range 21–27) days
DAOH-30 (sugammadex vs neostigmine-based reversal) · 30 days
- Similar DAOH-30
Patient-reported quality of recovery
- Similar with sugammadex vs control (11 trials, varied depending on metric used)
Original publication
The effect of sugammadex on patient morbidity and quality of recovery after general anaesthesia: a systematic review and meta-analysis. Br J Anaesth. Published 29 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →