Cardiothoracic & vascular anesthesia
The Effects of Dexmedetomidine on Postoperative Delirium in Adult Cardiac Surgical Patients: A Bayesian Meta‐Analysis and Trial Sequential Analysis
Pooled result · Delirium preventionResult — go to the resultRelative risk 0.76 95% CrI 0.56–1.00Authors' conclusion
Dexmedetomidine may reduce the risk of delirium among adults following cardiac surgery; however, uncertainty remains due to heterogeneity.
Study context
- Population
- Adults (> 18 years) undergoing cardiac surgery27 studies
- Comparison
- Dexmedetomidine vs another drug or placebo
- Outcome
- Incidence of postoperative delirium in the Intensive Care Unit (ICU)
Methodological detailstrial sequential analysis, meta-regression, Robust Bayesian Model Averaging, empirical prior, ROB-2 risk of bias, GRADE
- Trial sequential analysis
- Meta-regression
- Robust Bayesian Model Averaging
- Empirical prior
- ROB-2 risk of bias
- GRADE
Pooled result
Delirium prevention
Relative risk
0.76
95% CrI 0.56–1.00
Dexmedetomidine vs Another drug or placebo
RR 0.76 (95% CrI 0.56–1.00)
As reported in the abstract
Further pooled results
Meta-regression and trial sequential analysis
- Baseline risk of delirium a strong indicator of increased effectiveness; trial sequential analysis indicates potential effectiveness
Risk of bias and certainty of evidence
- Low risk of bias (studies)
- 19
- Some risk of bias (studies)
- 6
- High risk of bias (studies)
- 2
- Certainty of evidence low overall
Original publication
The Effects of Dexmedetomidine on Postoperative Delirium in Adult Cardiac Surgical Patients: A Bayesian Meta‐Analysis and Trial Sequential Analysis. Acta Anaesthesiol Scand. Published 9 June 2025. doi:10.
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