The effects of vasopressor choice on renal outcomes in septic shock: a systematic review of randomised trials as a guide for future research
Authors' conclusion
It illustrates the paucity of evidence supporting a particular vasopressor.
Study context
- Population
- Adults with septic shock
- Participants
- 4,259 adults · 17 studies
- Comparison
- Different vasopressors or vasopressor vs placebo
- Outcome
- Incidence of AKI
Methodological detailsprospectively registered
- Prospectively registered
Pooled result
As reported in the abstract
AKI rate (8 studies)
- No effect of vasopressor choice on acute kidney injury (AKI) rate
Further pooled results
Renal replacement therapy (RRT) rate, vasopressin studies
- Only 1 of 5 vasopressin studies showed significant benefit
- Most reported secondary outcome
Other secondary outcomes
- No conclusive benefit; limited reporting
- No studies reported long-term RRT requirement, Major Adverse Kidney Events (MAKE) 30 or 90
Original publication
The effects of vasopressor choice on renal outcomes in septic shock: a systematic review of randomised trials as a guide for future research. Crit Care. Published 2 October 2025. doi:10.
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