The Efficacy of Gabapentin in Reducing Perioperative Opioid Requirements in Pediatric Cardiac Surgery: A Randomized, Double-Blinded Controlled Study
Authors' conclusion
Perioperative gabapentin administration effectively reduces opioid requirements, provides effective postoperative analgesia as assessed by the MOPS, and accelerates recovery in pediatric cardiac surgery.
Study context
- Population
- Children aged 3 to 12 years undergoing elective corrective cardiac surgery with CPB, university children's hospital
- Participants
- 80 children
- Comparison
- G vs P
- Primary endpoint
- Total rescue fentanyl consumption (µg/kg)
- Follow-up
- First 48 postoperative hours
Methodological detailsprospective, double-blinded, placebo-controlled, single-centre
- Prospective
- Double-blinded
- Placebo-controlled
- Single-centre
Primary result
As reported in the abstract
P < 0.001
Secondary outcomes
Intraoperative opioid use, postoperative pain score (Modified Objective Pain Score (MOPS)), time to extubation, intensive care unit (ICU) LOS
- Reduced intraoperative opioid use, lower postoperative pain score, shorter time to extubation and decreased ICU LOS with gabapentin
Safety
- No increase in adverse events with gabapentin
Original publication
The Efficacy of Gabapentin in Reducing Perioperative Opioid Requirements in Pediatric Cardiac Surgery: A Randomized, Double-Blinded Controlled Study. J Cardiothorac Vasc Anesth. Published 6 March 2026. doi:10.
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