The impact of norepinephrine dose reporting heterogeneity on mortality prediction in septic shock patients
Authors' conclusion
Heterogeneous reporting of NE doses significantly affects mortality prediction in septic shock.
Study context
- Population
- Septic shock patients in the MIMIC-IV database
- Participants
- 4,086 patients
- Exposure
- Norepinephrine (NE) dose reported as salt formulations (bitartrate, tartrate) vs base molecule for 28-day mortality prediction
- Outcome
- Prediction of 28-day mortality by NE dose at common severity dose cut-offs
- Follow-up
- 28 days
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
As reported in the abstract
28-day mortality prediction by NE dose formulation
Lower ORs
65 %
95% CI 79–43
Bitartrate
Lower ORs
67 %
95% CI 80–47
Tartrate
Observational data: associations, not effects.
Further findings
%
| Outcome | Tartrate | Base molecule |
|---|---|---|
| Predicted mortality at 1 μg/kg/min threshold | 54 (95% CI 52–56) | 83 (95% CI 80–87) |
Cohort characteristics and observed outcome
- Median age, years
- 68 [57-78]
- Admission SOFA score
- 7 [6-10]
- Lactate at diagnosis, mmol/L
- 3.2 [2.4-5.1]
- Median peak NE dose at day 1, μg/kg/min
- 0.24 [0.12-0.42]
- 28-day mortality
- 39.3%
Original publication
The impact of norepinephrine dose reporting heterogeneity on mortality prediction in septic shock patients. Crit Care. Published 3 July 2024. doi:10.
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