The impact of pre‐operative depression on pain outcomes after major surgery: a systematic review and meta‐analysis
Authors' conclusion
Overall, pre-existing depression before surgery was associated with worse pain severity postoperatively.
Study context
- Population
- Patients undergoing major surgery
- Participants
- 501,962 patients · 60 studies
- Comparison
- Pre-operative depression vs no depression
- Outcome
- Postoperative pain scores at different time intervals
Methodological detailsmultilevel random effects meta-analysis
- Multilevel random effects meta-analysis
Pooled result
As reported in the abstract
Postoperative pain scores
Depression vs No depressionSMD (95% CI)P value
< 72 h; I2 = 41%; moderate certainty
0.97(0.37–1.56)
P = 0.0093-6 months; I2 = 83%; very low certainty
0.54(−0.06-1.15)
P = 0.07> 6 months; I2 = 78%; low certainty
0.45(0.23–0.68)
P < 0.001Further pooled results
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| Change in pain scores from pre-operative baseline · 1-2 years after surgeryI2 = 54%; very low certainty | 0.13 (−0.06-0.32) | P = 0.15 | |
| −0.200.20.4Difference (linear scale) |
Change in pain scores from pre-operative baseline · 1-2 years after surgery
- Similar between patients with and without pre-operative depression
Original publication
The impact of pre‐operative depression on pain outcomes after major surgery: a systematic review and meta‐analysis. Anaesthesia. Published 4 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →