Pediatric anesthesia & critical care
The Influence of Pharmacogenetic Factors on the Pharmacokinetics of Morphine and Its Metabolites in Pediatric Patients: A Systematic Review
Authors' conclusion
Although the available evidence suggests a potential genetic contribution to the variability in morphine concentration, the heterogeneity of the included studies in terms of experimental design and small sample sizes in some studies makes it challenging to propose the use of genetic biomarkers to personalize morphine dosing.
Study context
- Population
- Children receiving morphine8 studies
- Outcome
- Effect of genetic factors on the pharmacokinetics of morphine and its main metabolites
Methodological detailsPRISMA guidelines, Embase and Medline searched; 188 articles screened
- PRISMA guidelines
- Embase and Medline searched; 188 articles screened
Pooled result
As reported in the abstract
- Genetic variants of selected metabolic enzymes and transporters may play a role in interindividual variability in morphine plasma concentrations
- SLC22A1 and ABCC3 variants had the most supporting evidence for influencing morphine and metabolite pharmacokinetics
Original publication
The Influence of Pharmacogenetic Factors on the Pharmacokinetics of Morphine and Its Metabolites in Pediatric Patients: A Systematic Review. Anesth Analg. Published 11 December 2024. doi:10.
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