Anaesthetic drugs & techniques

The NARCOguide index – a novel parameter for monitoring depth of hypnosis during anaesthesia/sedation with propofol: A comparison study with the Narcotrend index

Eur J Anaesthesiol Intensive CarePublished Method comparison study

Primary result · Agreement of depth of anaesthesia indexResult — go to the resultBland-Altman MD −2.3

Authors' conclusion

The NARCOguide index can be used to monitor the hypnotic component of anaesthesia in patients undergoing general anaesthesia or sedation with propofol, with a performance similar to that of the Narcotrend index.

Study context

Population
Adults receiving GA (oral surgery, propofol/remifentanil/rocuronium) or light GA/deep sedation with propofol alone (laryngoscopic upper airway exploration)
Participants
40 adults
Comparison
NARCOguide index vs Narcotrend index
Primary endpoint
Agreement between NARCOguide and Narcotrend index (1-min averages at defined clinical markers; linear regression, Bland-Altman)
Methodological detailspost hoc analysis, two study centres
  • Post hoc analysis
  • Two study centres

Primary result

Agreement of depth of anaesthesia index

Bland-Altman MD

−2.3

As reported in the abstract

Correlation r 2
0.76

Further findings

Detection of burst suppression (vs human scoring) · over the entire dataset

Precision

Recall

Detection of burst suppression (vs human scoring)

Precision and recall in a similar range

Original publication

The NARCOguide index – a novel parameter for monitoring depth of hypnosis during anaesthesia/sedation with propofol: A comparison study with the Narcotrend index. Eur J Anaesthesiol Intensive Care. Published 18 July 2024. doi:10.1097/ea9.0000000000000057

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