Perioperative medicine & outcomes
The perioperative impact of frailty and cognitive impairment in older surgical patients: A multicentered longitudinal cohort study
Authors' conclusion
Patients with preoperative CI were significantly more frail at all perioperative time points than those without. While preoperative prefrailty/frailty was associated with significantly worse 30-day outcomes, only patients with combined prefrailty/frailty and CI experienced worse long-term outcomes at 90 days.
Study context
- Population
- Older non-cardiac surgical patients
- Participants
- 370 patients
- Exposure
- CI vs no-CI; prefrail/frail vs robust
- Outcome
- Preoperative prefrailty/frailty prevalence and frailty trajectory
Methodological detailsmulticentred
- Multicentred
Main finding
As reported in the abstract
| Group | Value | Prefrail | Frail |
|---|---|---|---|
| CI | 81% | 49% | 32% |
CI
- All patients: preoperative prefrailty or frailty
- 63%
- All patients: preoperative prefrailty
- 48%
- All patients: preoperative frailty
- 15%
Observational data: associations, not effects.
Further findings
LOS, non-home discharge, composite outcomes (prefrail/frail vs robust) · 30 days
- Prefrail/frail: longer LOS, more non-home discharge and composite outcomes than robust
Composite outcomes (prefrailty/frailty + CI vs prefrailty/frailty alone) · 90 days
- Significantly worse with combined prefrailty/frailty and CI
Risk factors for preoperative frailty (multivariable analysis)
- Female
- 3-fold
- Orthopedic surgery
- 7-fold
- Significant preoperative functional disability
- 6-fold
- High risk of OSA
- 5-fold
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →