The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia
Authors' conclusion
Patients with sepsis due to CAP exhibit a time-dependent and partially disease-specific shift in their plasma lipidome that correlates with disease severity and systemic inflammation and is associated with higher mortality.
Study context
- Population
- ICU patients with sepsis due to community-acquired pneumonia (CAP)82 reanalyzed at day 4
- Participants
- 169 / 51 / 48
- Exposure
- Sepsis due to CAP vs noninfected ICU patients and outpatient controls
- CAP sepsisn = 169
- Noninfected ICUn = 51
- Outpatient controlsn = 48reference
- Outcome
- Plasma lipids vs outpatient controls
Methodological detailspaired analysis, external validation cohorts
- Paired analysis
- External validation cohorts
Main finding
As reported in the abstract
Plasma lipids significantly lower in CAP sepsis vs outpatient controls
58%
Plasma lipids higher
6%
Plasma lipids not different
36%
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| 30-day mortality per 10% increase in cholesterol ester levels · absolute mortality, 18 of 82 | 0.84 | P = 0.006 |
Associations with disease severity and inflammatory biomarkers
- Strong lipid class-specific associations with disease severity (validated in two external cohorts) and inflammatory biomarkers; strongest for triacylglycerols, cholesterol esters and lysophospholipids
Change in lipids over time · 4 days after admission
- Lipids increased over time
- 36%
- Diverging lipid recovery by survival, confirmed in an external cohort
Comparison with noninfected ICU patients
- Common illness response
- 57.5%
- Distinct lipidomic signal for CAP sepsis
- 37%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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