Pediatric anesthesia & critical care
The Protective Effect of Remote Ischemic Preconditioning on Acute Kidney Injury Following Pediatric Cardiac Surgery: A Systematic Review and Meta-Analysis
Pooled resultResult — go to the resultOdds ratio 0.38 95% CI 0.25–0.60Authors' conclusion
The data indicate that RIPC significantly reduced the incidence of AKI after pediatric cardiac surgery, showing its potential renoprotective effect.
Study context
- Population
- Children undergoing cardiac surgery
- Participants
- 1,098 children · 6 randomized controlled trials (RCTs)
- Comparison
- RIPC vs control
- Outcome
- Incidence of postoperative acute kidney injury (AKI)
Methodological detailssensitivity analyses
- Sensitivity analyses
Pooled result
As reported in the abstract
Odds ratio
0.38
95% CI 0.25–0.60
P < 0.00001
RIPC vs Control
OR 0.38 (95% CI 0.25–0.60); P < 0.00001
Further pooled results
Postoperative serum creatinine (sCr), tumor necrosis factor (TNF)-α levels and intensive care unit (ICU) length of stay (LOS)
- No significant effect (p > 0.05 for all)
- I² >80%
Sensitivity analyses
- Large impact of some studies on the results
Original publication
The Protective Effect of Remote Ischemic Preconditioning on Acute Kidney Injury Following Pediatric Cardiac Surgery: A Systematic Review and Meta-Analysis. J Cardiothorac Vasc Anesth. Published 17 May 2025. doi:10.
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