Respiratory failure & ventilation
The relationship between the chronological phases of diffuse alveolar damage and clinical outcomes in acute respiratory distress syndrome
Main finding · 28-day and 60-day mortality by rapid progressionResult — go to the resultHazard ratio 2.274Authors' conclusion
Rapid progression of DAD was associated with significantly poorer clinical outcomes, and patients with rapid progression had significantly lower PaCO2 before lung biopsy.
Study context
- Population
- Patients with acute respiratory distress syndrome (ARDS) and histologically confirmed diffuse alveolar damage (DAD) on open lung biopsy (2002–2025) or transbronchial lung cryobiopsy (2017–2025)
- Participants
- 90 patients
- Exposure
- Rapid vs no rapid progression of DAD; proliferative vs fibrotic phase
- Outcome
- 28-day and 60-day mortality by rapid progression
Main finding
As reported in the abstract
Hazard ratio
2.274
P = 0.014
By group
Observational data: associations, not effects.
Further findings
| Outcome | Rapid progression | Without rapid progression | Proliferative phase | Fibrotic phase | P value |
|---|---|---|---|---|---|
| 28-day mortality, proliferative vs fibrotic phase · no significant difference | — not stated in the abstract | — not stated in the abstract | 36.5% | 43.5% | P = 0.556 |
| 60-day mortality, proliferative vs fibrotic phase · no significant difference | — not stated in the abstract | — not stated in the abstract | 63.5% | 69.9% | P = 0.601 |
| PaCO2 before lung biopsyRapid progression vs Without rapid progression | 43.4 ± 11.2 mmHg | 51.2 ± 21.1 mmHg | — not stated in the abstract | — not stated in the abstract | P = 0.013 |
— not stated in the abstract
Safety
Pneumothorax (most common biopsy-related complication)
- Pneumothorax, all patients
- 17.8%
Original publication
The relationship between the chronological phases of diffuse alveolar damage and clinical outcomes in acute respiratory distress syndrome. J Intensive Care. Published 10 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →