The Road to Precision Medicine for Acute Kidney Injury
Authors' conclusion
AKI is a syndrome that encompasses a wide range of underlying pathologies, and this heterogeneity has hindered the development of novel therapeutics for AKI.
Study context
- Population
- Critically ill patients with acute kidney injury (AKI)
Methodological detailsqualitative assessment, narrative synthesis, Sources: English-language observational studies, randomized clinical trials, reviews, professional society recommendations and guidelines on precision medicine in AKI
- Qualitative assessment
- Narrative synthesis
- Sources: English-language observational studies, randomized clinical trials, reviews, professional society recommendations and guidelines on precision medicine in AKI
Main finding
As reported in the abstract
- AKI is a syndrome of a wide range of underlying pathologies; this heterogeneity has hindered development of novel AKI therapeutics
- Efforts to improve precision in AKI: validation of novel AKI biomarkers, leveraging electronic health records (EHRs) for disease classification, phenotyping of tubular secretory clearance
- Ongoing efforts (Kidney Precision Medicine Project, AKI subphenotypes, optimised clinical trials and endpoints) hold great promise
Original publication
The Road to Precision Medicine for Acute Kidney Injury. Crit Care Med. Published 13 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →