Cardiothoracic & vascular anesthesia
Effect of Urine Output on the Predictive Precision of NephroCheck in On-Pump Cardiac Surgery With Crystalloid Cardioplegia: Insights from the PrevAKI Study
Authors' conclusion
NephroCheck measured 4 hours after the discontinuation from the CPB predicts moderate to severe AKI.
Study context
- Population
- Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) and crystalloid cardioplegia, university hospital337 included
- Participants
- 354 patients
- Comparison
- NephroCheck vs Serum creatinine
- Primary endpoint
- Correlation between UO, NephroCheck results and AKI (KDIGO)
- Follow-up
- 4 hours after CPB discontinuation
Methodological detailsPrevAKI
- PrevAKI
Primary result
As reported in the abstract
AKI prediction and correlation with UO
| Group | AUROC |
|---|---|
| NephroCheck | 0.60 (95% CI, 0.54-0.65) |
| Serum creatinine | 0.82 (95% CI, 0.78-0.86; p < 0.001) |
AUROC
NephroCheck0.60 (95% CI, 0.54-0.65)
Serum creatinine0.82 (95% CI, 0.78-0.86; p < 0.001)
- Correlation of NephroCheck with urine output (UO) at time of measurement (ρ)
- −0.17; p = 0.002
- Median NephroCheck, overall population ((ng/mL)2/1,000)
- 0.06
- Median NephroCheck, moderate to severe acute kidney injury (AKI) ((ng/mL)2/1,000)
- 0.15
Further findings
| Outcome | NephroCheck | Serum creatinine |
|---|---|---|
| Prediction of moderate to severe AKI | ||
| AUROC | 0.82 (95% CI, 0.77 to 0.86; p<0.0001) | 0.83 (95% CI, 0.79-0.87; p = 0.001) |
Original publication
Effect of Urine Output on the Predictive Precision of NephroCheck in On-Pump Cardiac Surgery With Crystalloid Cardioplegia: Insights from the PrevAKI Study. J Cardiothorac Vasc Anesth. Published 24 April 2024. doi:10.
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