Cardiothoracic & vascular anesthesia
The role of methadone in cardiac surgery for management of postoperative pain
Authors' conclusion
Intraoperative administration of methadone was associated with better pain control without significant side-effects after cardiac surgery.
Study context
- Population
- Patients undergoing cardiac surgery with CPB, 2018 to 2023
- Participants
- 11,967 patients
- Exposure
- Intraoperative methadone vs no methadone
- Outcome
- Mean pain scores
- Follow-up
- Until POD 7
Methodological detailssingle health system
- Single health system
Main finding
As reported in the abstract
- Lower mean pain scores in Groups M and M+O vs Group O after adjusting for covariates
- P<0.01
Observational data: associations, not effects.
Further findings
Hours until initial postoperative opioid
Total opioid administered · POD0-POD6
- Lower in Groups M and M+O vs Group O for all days
- all P<0.001
Safety
Postoperative complications
- Incidence did not differ between groups
Original publication
The role of methadone in cardiac surgery for management of postoperative pain. BJA Open. Published 22 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →