Neuroanesthesia & neurocritical care
The time constant of the cerebral arterial bed: exploring age-related implications
Authors' conclusion
τ is potentially an integrative marker of the changes occurring in cerebral vasculature, as it encompasses the interplay between changes in compliance and resistance that occur with age.
Study context
- Population
- Healthy volunteers across different age groups
- Participants
- 77 volunteers
- Exposure
- Young vs older healthy volunteers
- Youngn = 52reference
- Oldn = 25
- Outcome
- Time constant of the cerebral arterial bed (τ), estimated from arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV) pulse waveforms
Main finding
As reported in the abstract
τ
P = 0.004
- τ significantly decreased with age (rS)
- - 0.27
Observational data: associations, not effects.
Further findings
CBFV · lower in older volunteers
P < 0.001
| Outcome | Young | Old | P value |
|---|---|---|---|
| Pulse amplitude of ABPHigher in older volunteers | 12.5 (IQR 10.9–14.4) mm Hg | 16.7 (IQR 14.6–19.4) mmHg | P < 0.001 |
Original publication
The time constant of the cerebral arterial bed: exploring age-related implications. J Clin Monit Comput. Published 4 April 2024. doi:10.
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