Neuroanesthesia & neurocritical care
Characterization of intracranial compliance in healthy subjects using a noninvasive method - results from a multicenter prospective observational study
Authors' conclusion
The study revealed that the P2/P1 ratio and TTP are influenced by age and sex in healthy individuals, with men displaying lower values than women, and both ratios increasing with age.
Study context
- Population
- Healthy volunteers of both sexes aged 9 to 74 years, monitored 5 min supine at 0º104 male
- Participants
- 188 volunteers
- Exposure
- P2/P1 ratio and time-to-peak (TTP) by sex and age group
- Outcome
- Intracranial compliance (noninvasive ICP waveform, P2/P1 ratio and TTP)
Methodological detailsmulticentre, noninvasive intracranial pressure (ICP) monitoring, December 2020 to February 2023, Median (IQR) age 41 (29-51); median (IQR) BMI 25.09 (22.57-28.04)
- Multicentre
- Noninvasive ICP monitoring
- December 2020 to February 2023
- Median (IQR) age 41 (29-51); median (IQR) BMI 25.09 (22.57-28.04)
Main finding
As reported in the abstract
P2/P1 ratio and TTP
- Men lower P2/P1 ratio and TTP than women
- p < 0.001
- Relative rise in P2/P1 and TTP with increasing age
- p < 0.001
Observational data: associations, not effects.
Original publication
Characterization of intracranial compliance in healthy subjects using a noninvasive method - results from a multicenter prospective observational study. J Clin Monit Comput. Published 20 July 2024. doi:10.
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