Thiamine administration in septic shock: a post hoc analysis of two randomized trials
Primary result · Alive and RRT-free, overall cohortResult — go to the resultAdjusted odds ratio 2.05 95% CI 1.08–3.90Authors' conclusion
In the combined analysis of two previous randomized trials, thiamine administration was associated with higher odds of being alive and RRT-free at hospital discharge in patients with septic shock. This signal was stronger in patients with thiamine deficiency.
Study context
- Population
- Patients with septic shock
- Participants
- 158 patients
- Comparison
- Thiamine vs no thiamine
- Primary endpoint
- Survival without receipt of RRT (alive and RRT-free)
Methodological detailspooled patient-level data, two Phase II trials
- Pooled patient-level data
- Two Phase II trials
Primary result
Alive and RRT-free, overall cohort
Adjusted odds ratio
2.05
95% CI 1.08–3.90
Thiamine vs No thiamine
aOR 2.05 (95% CI 1.08–3.90)
As reported in the abstract
Further findings
| Outcome | Estimate | |
|---|---|---|
| Not needing RRT, overall cohortThiamine vs Placebo | aOR for not needing RRT 2.59 (95% CI 1.01–6.62) | |
| Alive and RRT-free, thiamine-deficient cohort (thiamine < 8 nmol/L) (subgroup)Thiamine vs Placebo | aOR for being alive and RRT-free 8.17 (95% CI 1.79–37.22) | |
| Survival to hospital discharge, thiamine-deficient cohort (subgroup)Thiamine vs Placebo | aOR for surviving to hospital discharge 6.84 (95% CI 1.54–30.36) | |
| 0.050.21520Ratio (log scale) |
- Alive and RRT-free, thiamine-deficient cohort (thiamine < 8 nmol/L) (subgroup): interaction, p = 0.016
- Survival to hospital discharge, thiamine-deficient cohort (subgroup): interaction p = 0.019
Original publication
Thiamine administration in septic shock: a post hoc analysis of two randomized trials. Crit Care. Published 6 February 2024. doi:10.
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