The outcome of IV vitamin C therapy in patients with sepsis or septic shock: a meta-analysis of randomized controlled trials
Pooled resultResult — go to the resultMD - 0.62 95% CI - 1.00 to - 0.25Authors' conclusion
In this meta-analysis, IVVC in sepsis or septic shock patients significantly improved delta SOFA score and reduced the duration of vasopressor use, whereas it was not associated with reduction in short-term mortality and had higher adverse events.
Study context
- Population
- Adults (≥ 18 years) with sepsis or septic shock
- Participants
- 3,364 adults · 18 randomized controlled trials (RCTs)
- Comparison
- IV vitamin C vs control
- Outcome
- Delta Sequential Organ Failure Assessment (SOFA) score
- Follow-up
- 72-96 h
Methodological detailsupdated meta-analysis
- Updated meta-analysis
Pooled result
As reported in the abstract
MD
- 0.62
95% CI - 1.00 to - 0.25
P = 0.001
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Short-term mortality | 0.89 (0.77–1.04) | P = 0.14 | |
| Short-term mortality (dose 25-100 mg/kg/d subgroup) | 0.80 (0.65–0.97) | P = 0.03 | |
| 0.512Odds ratio (log scale) |
| Outcome | MD (95% CI) | P value |
|---|---|---|
| Duration of vasopressor use | - 15.07 (- 21.59 to - 8.55) | P < 0.00001 |
Safety
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Adverse events | 1.98 (1.06–3.68) | P = 0.03 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
The outcome of IV vitamin C therapy in patients with sepsis or septic shock: a meta-analysis of randomized controlled trials. Crit Care. Published 13 March 2023. doi:10.
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