Association of Vitamin C, Thiamine, and Hydrocortisone Infusion With Long-term Cognitive, Psychological, and Functional Outcomes in Sepsis Survivors: A Secondary Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Randomized Clinical Trial
An erratum to this article was published (JAMA Netw Open, 3 Apr 2023 ↗)
Authors' conclusion
In survivors of sepsis, treatment with vitamin C, thiamine, and hydrocortisone did not improve or had worse cognitive, psychological, and functional outcomes at 6 months compared with patients who received placebo.
Study context
- Population
- Adults with sepsis-induced respiratory and/or cardiovascular dysfunction who survived to discharge or day 30, 43 US ICUslong-term outcomes assessed
- Participants
- 213 adults
- Comparison
- IV vitamin C, thiamine and hydrocortisone vs placebo
- Interventionn = 108
- Controln = 105reference
- Primary endpoint
- Cognitive performance, risk of posttraumatic stress disorder and depression, and functional status (standardized instruments by telephone)
- Follow-up
- 6 months after randomization
Methodological detailsprespecified secondary analysis, multicentre, double-blind, placebo-controlled
- Prespecified secondary analysis
- Multicentre
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Long-term cognitive, psychological and functional outcomes · 6 months
Intervention vs ControlAdjusted odds ratio (95% CI)
Immediate memory scores (lower)
0.49(0.26–0.89)
Posttraumatic stress disorder
3.51(1.18–10.40)
Receiving mental health care
0.38(0.16–0.89)
Original publication
Association of Vitamin C, Thiamine, and Hydrocortisone Infusion With Long-term Cognitive, Psychological, and Functional Outcomes in Sepsis Survivors: A Secondary Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Randomized Clinical Trial. JAMA Netw Open. Published 1 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →