Early administration of vitamin C in patients with sepsis or septic shock in emergency departments: a multicenter, double-blind, randomized controlled trial: the C-EASIE trial
Authors' conclusion
Early treatment with vitamin C did not result in a statistically significant reduction in organ dysfunction.
Study context
- Population
- Patients with sepsis or septic shock in the EDs of 8 hospitals throughout Belgium292 analysed
- Participants
- 300 patients
- Comparison
- Vitamin C 1.5 g every 6 h for 4 days vs matching placebo
- Vitamin Cn = 147
- Placebon = 145reference
- Primary endpoint
- Average post-baseline patient SOFA score on day 2 to 5
- Follow-up
- Day 2 to 5
Methodological detailsphase 3b, prospective, multicentre, double-blinded, placebo-controlled, Recruited between June 4th, 2021, and August 19th, 2023
- Phase 3b
- Prospective
- Multicentre
- Double-blinded
- Placebo-controlled
- Recruited between June 4th, 2021, and August 19th, 2023
Primary result
As reported in the abstract
Ratio
0.91
95% CI 0.77–1.08
P = 0.30
By group
Vitamin C
1.98
Placebo
2.19
Secondary outcomes
| Outcome | Ratio (95% CI) | P value |
|---|---|---|
| Average post-baseline SOFA score, baseline SOFA score ≥6 (planned subgroup) | 0.76 (0.86–0.99) | P = 0.042 |
| Being on RRT (per protocol analysis)Per protocol analysis | 0.28 (0.078–1.0) | P = 0.05 |
Key secondary outcomes (maximum Sequential Organ Failure Assessment (SOFA) score, 28-day mortality, ICU and hospital LOS)
- Similar in the two groups
Safety
Adverse events
- Similar in the two groups
Original publication
Early administration of vitamin C in patients with sepsis or septic shock in emergency departments: a multicenter, double-blind, randomized controlled trial: the C-EASIE trial. Crit Care. Published 23 April 2025. doi:10.
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