EFFECT of daily antiseptic bathing with octenidine on ICU-acquired bacteremia and ICU-acquired multidrug-resistant organisms: a multicenter, cluster-randomized, double-blind, placebo-controlled, cross-over study
An erratum to this article was published (Intensive Care Med, Apr 2025 ↗)
Primary result · ICU-acquired primary bacteremia and ICU-acquired MDROsResult — go to the resultAdjusted hazard ratio 0.83 95% CI [0.75; 0.92]Authors' conclusion
Antiseptic bathing with octenidine may be effective in preventing ICU-acquired primary bacteremia, particularly due to Gram-positive bacteria and common skin commensals.
Study context
- Population
- ICU episodes on 44 intensive care units (ICUs) in 23 hospitals throughout Germany
- Participants
- 93,438 participants · 104,039 ICU episodes
- Comparison
- Daily bathing with octenidine-impregnated vs placebo washcloths
- Primary endpoint
- ICU-acquired primary bacteremia and ICU-acquired MDROs (algorithmically derived)
Methodological detailsmulticentre, double-blind, placebo-controlled, cross-over, ICUs compared with themselves over two 12-month periods, Data obtained digitally from hospital information systems
- Multicentre
- Double-blind
- Placebo-controlled
- Cross-over
- ICUs compared with themselves over two 12-month periods
- Data obtained digitally from hospital information systems
Primary result
As reported in the abstract
ICU-acquired primary bacteremia and ICU-acquired MDROs
Adjusted hazard ratio
0.83
95% CI [0.75; 0.92]
P = 0.0003
Octenidine vs Placebo
adjusted HR 0.83 (95% CI [0.75; 0.92]); P = 0.0003
- ICU-acquired multidrug-resistant organisms (MDROs): no intervention effect
- adjusted HR 0.98 0.98 (95% CI [0.83; 1.15])
Further findings
Pathogens in bacteremia reduction
- Coagulase-negative staphylococci
- 53%
- Enterococci
- 17%
Original publication
EFFECT of daily antiseptic bathing with octenidine on ICU-acquired bacteremia and ICU-acquired multidrug-resistant organisms: a multicenter, cluster-randomized, double-blind, placebo-controlled, cross-over study. Intensive Care Med. Published 17 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →