Gut colonization with multidrug resistant organisms in the intensive care unit: a systematic review and meta-analysis
Authors' conclusion
Acquisition of gut MDRO was common in the ICU and increases with days spent in ICU through 30 days of follow-up.
Study context
- Population
- Intensive care unit (ICU) patients with perianal or rectal swabs at ICU admission (within 48 h) and at ≥1 subsequent timepoint; studies 2010–2023
- Participants
- 37,305 patients · 14 studies
- Outcome
- Incidence rate of gut acquisition of MDRO (multidrug resistant non-Pseudomonas Gram-negative bacteria, Pseudomonas spp., VRE) newly detected after ICU admission, for all patient-time at risk
Pooled result
As reported in the abstract
Gut acquisition of MDRO · during ICU hospitalization
Pooled incidence rate per 1000 patient-days
12.2
95% CI 8.1–18.6
Pooled incidence (range: 1-43%)
5%
Further pooled results
Median time to acquisition
- Ranged from 4 to 26 days after ICU admission
NP-GN and Pseudomonas spp. (subgroup)
- Results similar for NP-GN and Pseudomonas spp.; insufficient data to assess vancomycin-resistant Enterococcus (VRE)
Daily increase in gut multidrug-resistant organisms (MDRO) colonization (curve fitting, 6 studies) · through 30 days of ICU hospitalization
- Quasi-linear increase per day, stable through 30 days (R2 = 0.50, p < 0.01)
- 1.41%
Original publication
Gut colonization with multidrug resistant organisms in the intensive care unit: a systematic review and meta-analysis. Crit Care. Published 28 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →