Intravenous vitamin C monotherapy in critically ill patients: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis
Pooled resultResult — go to the resultRelative risk 0.73 95% CI 0.60–0.89Authors' conclusion
IVVC monotherapy may be associated with mortality benefits in critically ill patients, particularly in patients with a high risk of dying.
Study context
- Population
- Adult critically ill patients
- Participants
- 2,130 patients · 16 randomized controlled trial (RCTs)
- Comparison
- Intravenous vitamin C monotherapy vs control
- Outcome
- Overall mortality
Methodological detailstrial sequential analysis, random effect meta-analysis, Four databases searched from inception to 22 June 2022 without language restrictions
- Trial sequential analysis
- Random effect meta-analysis
- Four databases searched from inception to 22 June 2022 without language restrictions
Pooled result
As reported in the abstract
Relative risk
0.73
95% CI 0.60–0.89
P = 0.002
IVVC vs Control
RR 0.73 (95% CI 0.60–0.89); P = 0.002
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Overall mortality, trials with control group mortality > 37.5% (subgroup)TSA supported this | 0.65 (0.54–0.79) | |
| Overall mortality, trials with control group mortality ≤ 37.5% (subgroup) | 0.89 (0.68–1.16) | |
| 0.512Relative risk (log scale) |
- Overall mortality, trials with control group mortality > 37.5% (subgroup): test for subgroup differences: p = 0.06
- Overall mortality, trials with control group mortality ≤ 37.5% (subgroup): test for subgroup differences: p = 0.06
Overall mortality, a priori subgroups (single vs multicentre, higher vs lower dose, sepsis vs non-sepsis) (subgroup)
- No differences between subgroups
Overall mortality, post-hoc subgroups (earlier vs delayed treatment, longer vs shorter duration, low vs other risk of bias) (subgroup)
- No differences between subgroups
- Post-hoc
Original publication
Intravenous vitamin C monotherapy in critically ill patients: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis. Ann Intensive Care. Published 7 March 2023. doi:10.
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