Three initial prophylactic phenylephrine infusion rates and physician interventions in patients with preeclampsia undergoing caesarean delivery under spinal anaesthesia: a randomised double-blind trial
Authors' conclusion
All three infusion regimens required a similar number of physician interventions to maintain systolic blood pressure close to the baseline.
Study context
- Population
- Patients with preeclampsia undergoing caesarean delivery under spinal anaesthesia
- Participants
- 102 patients
- Comparison
- 15 µg/min vs 25 µg/min vs 35 µg/min
- Primary endpoint
- Number of physician interventions
Methodological detailsdouble-blind
- Double-blind
Primary result
As reported in the abstract
15 µg/min
6.5
median · IQR 4–9
25 µg/min
6
median · IQR 4–7.5
35 µg/min
6.5
median · IQR 4–9
P = 0.831
Secondary outcomes
Events
| Outcome | 15 µg/min | 25 µg/min | 35 µg/min | P value |
|---|---|---|---|---|
| Hypotension15 µg/min vs 25 µg/min vs 35 µg/min · three-group comparison | 19 | 19 | 22 | P = 0.695 |
Total phenylephrine dose
- Greater with higher infusion doses
- P < 0.001
Safety
Bradycardia
- No patient had bradycardia
Hypertension
- One patient had hypertension
- 1
Neonatal outcome and maternal complications
- Not different among groups
Original publication
Three initial prophylactic phenylephrine infusion rates and physician interventions in patients with preeclampsia undergoing caesarean delivery under spinal anaesthesia: a randomised double-blind trial. Int J Obstet Anesth. Published 2 December 2025. doi:10.
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