Thromboembolic and bleeding events in intensive care unit (ICU) patients with COVID‐19: A nationwide, observational study
Authors' conclusion
Both thromboembolic and bleeding events frequently occurred in ICU patients with COVID-19.
Study context
- Population
- All ICU patients with COVID-19 in Denmark, 10th March 2020 to 30th June 2021 (first and second waves)
- Participants
- 1,369 patients
- Outcome
- Occurrence of thromboembolic and bleeding events during ICU stay
Methodological detailssub-study of the Danish Intensive Care Covid database
- Sub-study of the Danish Intensive Care Covid database
Main finding
As reported in the abstract
Thromboembolic and bleeding events in ICU
Thromboembolic event, n
% 158 (12%) (95% CI 10-13)
Bleeding event, n
% 309 (23%) (95% CI 20-25)
Major bleeding, n
% 81 (6%) (95% CI 4.8-7.3)
Observational data: associations, not effects.
Further findings
Association with 90-day mortality (adjusted Cox regression)
| HR (CI) | P value | ||
|---|---|---|---|
| Thromboembolic eventsNot associated with mortality · adjusted analysis | 1.35 (0.91–2.01) | P = 0.14 | |
| Bleeding eventsAdjusted analysis | 1.55 (1.18–2.05) | P = 0.002 | |
| 0.512Hazard ratio (log scale) |
Variables associated with thrombosis and bleeding
- Mechanical ventilation and increased D-dimer associated with thrombosis
- Mechanical ventilation, low platelet count and haematological malignancy associated with bleeding
Increased doses of thromboprophylaxis during ICU stay
- Patients receiving increased doses
- 76%
Original publication
Thromboembolic and bleeding events in ICU patients with COVID‐19: A nationwide, observational study. Acta Anaesthesiol Scand. Published 6 November 2022. doi:10.
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