Tight Blood-Glucose Control without Early Parenteral Nutrition in the Intensive Care Unit (ICU)
Primary resultResult — go to the resultHR for earlier discharge alive 1.00 95% CI 0.96–1.04Authors' conclusion
In critically ill patients who were not receiving early parenteral nutrition, tight glucose control did not affect the length of time that ICU care was needed or mortality.
Study context
- Population
- Patients on ICU admission, without early parenteral nutrition
- Participants
- 9,230 patients
- Comparison
- Tight glucose control vs Liberal glucose control
- Tight glucose controln = 4,608
- Liberal glucose controln = 4,622reference
- Primary endpoint
- Length of time ICU care was needed (time to discharge alive from ICU, death as competing risk)
Primary result
As reported in the abstract
HR for earlier discharge alive
1.00
95% CI 0.96–1.04
P = 0.94
Tight glucose control vs Liberal glucose control
HR for earlier discharge alive 1.00 (95% CI 0.96–1.04); P = 0.94
Secondary outcomes
Morning blood glucose
90-day mortality (safety outcome)
P = 0.51
90-day mortality (safety outcome) · similar
P = 0.51
Eight prespecified secondary outcomes
- New infections, duration of respiratory and hemodynamic support, time to discharge alive from hospital, ICU and hospital mortality similar in the two groups
- Severe AKI and cholestatic liver dysfunction appeared less prevalent with tight glucose control
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU. N Engl J Med. Published 28 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →