Cardiac arrest & resuscitation
Time in therapeutic range for targeted temperature management and outcomes following out-of-hospital cardiac arrest
Authors' conclusion
Among patients with OHCA who underwent TTM, we found variability in adherence to guideline-recommended treatment targets. Higher TTR was not associated with overall survival, but for certain temperature thresholds, TTR was associated with favorable neurologic outcome.
Study context
- Population
- Adults with out-of-hospital cardiac arrest (OHCA) who underwent targeted temperature management (TTM) for >12 h, ROC-Continuous Chest Compressions trial
- Participants
- 2,637 adults
- Exposure
- Time in therapeutic range during TTM and outcomes
- Outcome
- Association of TTR 32 °C-36 °C with outcomes
Main finding
As reported in the abstract
TTR 32 °C-36 °COdds ratio (95 % CI)
Overall survival; risk-adjusted
1.00(0.90–1.10)
Favorable neurologic outcome; risk-adjusted
1.02(0.90–1.14)
- Median time-in-therapeutic range (TTR) 32 °C-36 °C, h (IQR 21-24)
- 23
- Median time outside therapeutic range, h (IQR 0.0-4.2)
- 0.9
Observational data: associations, not effects.
Further findings
Association of TTR 33 °C-36 °C with outcomes
| OR (CI) | ||
|---|---|---|
| TTR 33 °C-36 °CFavorable neurologic survival | 1.12 (1.01–1.25) | |
| TTR 33 °C-36 °COverall survival | 1.04 (0.94–1.15) | |
| 0.512Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Time in therapeutic range for targeted temperature management and outcomes following out-of-hospital cardiac arrest. Resuscitation. Published 25 November 2022. doi:10.
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