Respiratory failure & ventilation
Time-varying intensity of ventilatory inefficiency and mortality in patients with acute respiratory distress syndrome
Authors' conclusion
Cumulative exposure to high intensities of VR may be associated with increased mortality in patients with ARDS.
Study context
- Population
- Intubated, mechanically ventilated acute respiratory distress syndrome (ARDS) patients; excluded extracorporeal life support or ventilation <1 day
- Participants
- 2,851 participants
- Comparison
- Longitudinal exposure to ventilatory inefficiency
- Primary endpoint
- 28-day mortality
- Follow-up
- 28 days
Methodological detailsFACTT, ALTA, EDEN, SAILS, ARDS Network, Bayesian joint models
- FACTT, ALTA, EDEN, SAILS
- ARDS Network
- Bayesian joint models
Primary result
As reported in the abstract
Hazard ratio (95% CI)
Daily increment in PaCO2adjusted; not associated with mortality
1.008(0.997–1.018)
Daily increment in VRadjusted; associated with increased mortality
1.548(1.309–1.835)
- Overall 28-day mortality rate
- 21.3%
Further findings
| Outcome | Estimate | |
|---|---|---|
| Daily exposure to VR > 2 and cumulative effectDaily exposure to VR > 2 | HR 1.088 per day (95% CI 1.034–1.147) | |
| Daily exposure to VR > 2 and cumulative effectCumulative VR > 2 exposure | HR 1.085 per area (95% CI 1.050–1.122) | |
| 0.512Hazard ratio (log scale) |
Daily exposure to ventilatory ratio (VR) > 2 and cumulative effect
- PaCO2 exposure insignificant
Duration of invasive mechanical ventilation
- Median duration, days (IQR: 4-28 days)
- 9
Original publication
Time-varying intensity of ventilatory inefficiency and mortality in patients with acute respiratory distress syndrome. Ann Intensive Care. Published 13 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →