Toward nutrition improving outcome of critically ill patients: How to interpret recent feeding randomized controlled trials (RCTs)?
Study context
- Population
- Critically ill patients
Main finding
As reported in the abstract
- Recent RCTs: early full nutritional support does not benefit critically ill patients and may induce dose-dependent harm
- RCTs revealed no subgroup benefiting from early full nutritional support, nor benefit from increased amino acid doses or indirect calorimetry-based energy dosing targeted at 100% of energy expenditure
- Mechanistic studies: absence of benefit attributed to anabolic resistance, futile catabolism of extra amino acids and feeding-induced suppression of autophagy and ketogenesis
- No large RCTs of feeding strategies initiated after the acute phase and continued after ICU discharge
Original publication
Toward nutrition improving outcome of critically ill patients: How to interpret recent feeding RCTs? Crit Care. Published 27 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →