Cardiothoracic & vascular anesthesia
Trajectories of Pain Scores and Analgesic Administration Following Cardiac Surgery
Authors' conclusion
Latent class trajectory modeling identified heterogeneous recovery patterns of pain and opioid use after cardiothoracic surgery.
Study context
- Population
- Adults undergoing cardiac surgery with CPB, 4 US hospital campuses, 2018–2023
- Participants
- 11,172 adults
- Primary endpoint
- Joint trajectories of postoperative pain scores (0-10 verbal rating scale) and opioid administration (MME)
- Follow-up
- POD 0-7
Methodological detailslatent class trajectory modeling, multicentre
- Latent class trajectory modeling
- Multicentre
Primary result
As reported in the abstract
Joint pain and MME trajectory classes
Distinct pain and MME trajectory classes identified, from low pain/low MMEs to escalating or persistent pain/high MMEs
8
Most favorable class (class 1: consistently low pain and low opioid use), proportion
13%
Further findings
Predictors of class 1 membership
- Class 1 more likely older, lower BMI, surgery in 2018 (vs 2023), intraoperative methadone; less likely preoperative chronic pain diagnosis
- Odds of class membership varied by demographics, procedure type and intraoperative analgesia
- Multinomial logistic regression
Original publication
Trajectories of Pain Scores and Analgesic Administration Following Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 1 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →