Trajectories of Survivors and Non-Survivors Post-burn Injury

Ann SurgPublished 16 Jun 2025Cohort study

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Authors' conclusion

Survivors and non-survivors showed distinct post-injury inflammatory and metabolic responses.

Study context

Population: Adults (≥ 18 years) with burn injuries ≥ 10% total body surface area admitted to a provincial burn centre
Participants: 872 adults

Exposure: Survivors vs early non-survivors vs late non-survivors
Survivorsn = 705reference
Early non-survivorsn = 99
Late non-survivorsn = 68

Methodological detailssingle-centre

As reported in the abstract

Non-survivors exhibited significantly elevated biomarkers vs survivors, with distinct metabolic and inflammatory profiles, incl. increased IL-1β, IL-8, TNF-α and IL-10
Late non-survivors: significant differences in inflammatory and metabolic responses over time

Observational data: associations, not effects.

Age — Survivors vs Early non-survivors · across the three groups

P < 0.0001

Survivorsmedian 46 yearsIQR 33–59

Early non-survivorsmedian 62 yearsIQR 46–73

Late non-survivorsmedian 67 yearsIQR 54–76

% TBSA burn — Survivors vs Early non-survivors · across the three groups

P < 0.0001

Survivorsmedian 17 %IQR 13–26

Early non-survivorsmedian 67 %IQR 43–88

Late non-survivorsmedian 27 %IQR 18–44

Trajectories of Survivors and Non-Survivors Post-burn Injury. Ann Surg. Published 16 June 2025. doi:10.1097/sla.0000000000006787

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