Vasopressor Use in Acute Burn Resuscitation: A Retrospective Study
Main finding · Acute kidney injuryResult — go to the resultOdds ratio 2.62 95% CI 2.20–3.11Authors' conclusion
While vasopressors are frequently administered as part of burn resuscitation, their use was associated with higher rates of early acute kidney injury and an increased 30-day mortality rate.
Study context
- Population
- Adults (≥ 18 years) with burns ≥ 20% total body surface area (TBSA), TriNetX records 2010–20231,206 per cohort after propensity score matching (PSM)
- Participants
- 6,872 adults
- Exposure
- Vasopressors within first 2 days of hospitalisation vs no vasopressors
- VP+n = 1,206
- VP-n = 1,206reference
- Outcome
- Acute kidney injury
- Follow-up
- Within 3 days
Methodological detailspropensity-score matched (1:1), Benjamini-Hochberg correction for multiple testing, TriNetX Research Network
- Propensity-score matched (1:1)
- Benjamini-Hochberg correction for multiple testing
- TriNetX Research Network
Main finding
As reported in the abstract
Odds ratio
2.62
95% CI 2.20–3.11
By group
VP+ vs VP-
OR 2.62 (95% CI 2.20–3.11)
Observational data: associations, not effects.
Further findings
| Outcome | VP+ | VP- | OR (95% CI) | |
|---|---|---|---|---|
| Mortality · within 30 daysPropensity-matched cohort | 45.1% | 32.7% | 1.69 (1.43–2.01) | |
| 0.512Odds ratio (log scale) |
Vasopressor use before matching · first 2 days
- Received vasopressors (of 6872); older, more comorbidities, more severe burns
- 17.7%
Safety
| Outcome | VP+ | VP- | OR (95% CI) | |
|---|---|---|---|---|
| Sepsis · within 30 daysPropensity-matched cohort | 30.8% | 22.9% | 1.50 (1.25–1.81) | |
| 0.512Odds ratio (log scale) |
Original publication
Vasopressor Use in Acute Burn Resuscitation: A Retrospective Study. Acta Anaesthesiol Scand. Published 28 January 2026. doi:10.
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