Burn Resuscitation Practices in North America: Results of the Acute Burn ResUscitation Multicenter Prospective Trial (ABRUPT)
Authors' conclusion
Albumin use is associated with older age, larger and deeper burns, and more severe organ dysfunction at presentation. Albumin supplementation is started when initial crystalloid rates are above expected targets and improves the I/O ratio. The fluid received in the first 24 hours was at or above the Parkland Formula estimate.
Study context
- Population
- Patients ≥18 years with burns ≥ 20% total body surface area (TBSA) at 21 North American burn centers
- Participants
- 379 patients · 21 burn centers
- Exposure
- Albumin supplemented to crystalloid vs crystalloid alone
- Albuminn = 253
- Crystalloidn = 126reference
- Outcome
- Burn resuscitation with albumin or crystalloids alone (hourly resuscitation parameters)
- Follow-up
- 48 hours
Methodological detailsnoninterventional, multicentre
- Noninterventional
- Multicentre
Main finding
As reported in the abstract
Total fluid received · 24 hours
Observational data: associations, not effects.
Further findings
In-to-out (I/O) ratio and timing of albumin
- Albumin lowered the I/O ratio; started ≤12 hours in patients with highest initial fluid requirements, >12 hours with intermediate requirements, avoided in crystalloid responders
Original publication
Burn Resuscitation Practices in North America: Results of the Acute Burn ResUscitation Multicenter Prospective Trial (ABRUPT). Ann Surg. Published 19 August 2021. doi:10.
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