A Prospective, Randomized, Multicenter Trial Comparing Lactated Ringer’s Alone or With 5% Albumin for Resuscitation of Large Burns The Acute Burn ResUscitation Multicenter Prospective Trial 2 (ABRUPT2)
- stopped early due to declining enrollment
Authors' conclusion
The use of 5% albumin significantly reduced fluid requirements compared to LR alone in the first 48 hours after injury.
Study context
- Population
- Adults (≥ 18 years) with burns ≥ 25% TBSA and ≥ 20% full-thicknessstopped early
- Participants
- 99 adults
- Comparison
- Albumin (Alb) vs lactated Ringer's (LR)
- Albn = 48
- LRn = 51reference
- Primary endpoint
- Resuscitation fluid requirements
- Follow-up
- 24 and 48 hours
Methodological detailsprospective, multicentre, crossover permitted for safety or excessive fluid volumes, Mean % TBSA burn 46%
- Prospective
- Multicentre
- Crossover permitted for safety or excessive fluid volumes
- Mean % TBSA burn 46%
Primary result
As reported in the abstract
Resuscitation fluids
Times higher fluids
1.5 ml/kg/%TBSA
95% CI 0.59,2.3; p 0.001
at 24 hours
Times higher fluids
2.1 ml/kg/%TBSA
95% CI 1.0,3.1; p 0.001
at 48 hours
Further findings
- No differences in mortality or time to healing
Safety
- No difference in AKI
Original publication
A Prospective, Randomized, Multicenter Trial Comparing Lactated Ringer’s Alone or With 5% Albumin for Resuscitation of Large Burns The Acute Burn ResUscitation Multicenter Prospective Trial 2 (ABRUPT2). Ann Surg. Published 18 May 2026. doi:10.
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